Antineutrophil cytoplasmic autoantibody positive vasculitis induced by propylthiouracil: a case report / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 379-382, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-236614
ABSTRACT
<p><b>OBJECTIVE</b>Propylthiouracil (PTU) as a drug used during the treatment of hyperthyroidism could induce antineutrophil cytoplasmic autoantibody-positive vasculitis. Here the author reported a childhood case of antineutrophil cytoplasmic autoantibody-positive vasculitis induced by PTU, which is rarely described.</p><p><b>METHODS</b>The diagnosis was made according to the symptoms, signs, serum markers and renal biopsy, and the relevant literature was reviewed.</p><p><b>RESULTS</b>The 12-year-old girl presented with gross hematuria, proteinuria, renal function damage [Ccr 52.46 ml/(min. 1.73 m(2))], positive antineutrophil cytoplasmic autoantibody (ANCA-MPO) (MPO ELISA 140%) and a vasculitis lesion in the renal biopsy sample. She had been treated with PTU for 5 years because of Graves disease. After the diagnosis, the PTU was withdrawn, and prednisone (40 mg/d) and cyclophosphamide (25 mg, Bid) were applied. Three weeks after the therapy with prednisone and cyclophosphamide the gross hematuria disappeared. Three months after the treatment the renal function returned to normal [Ccr 124 mg/(min.1.73 m(2))], and the titer of ANCA-MPO decreased from 140% to 57%.</p><p><b>CONCLUSION</b>PTU may induce antineutrophil cytoplasmic autoantibody positive vasculitis. A right diagnosis and treatment can improve its prognosis of the disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Propiltiouracila
/
Terapêutica
/
Antitireóideos
/
Vasculite
/
Sangue
/
Resultado do Tratamento
/
Anticorpos Anticitoplasma de Neutrófilos
/
Usos Terapêuticos
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Pediatrics
Ano de publicação:
2004
Tipo de documento:
Artigo
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