Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 201-206, 2013.
Article
em Zh
| WPRIM
| ID: wpr-236838
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and toxicities after high-dose methotrexate (HD-MTX) infusion in children with acute lymphocytic leukemia (ALL).</p><p><b>METHODS</b>MTHFR variants in 52 children with ALL were determined by reverse transcriptase-polymerase chain reaction-denaturing gradient gel electrophoresis and sequencing. Toxicities of children who received HD-MTX chemotherapy were evaluated according to the National Cancer Institute-Common Toxicity Criteria (NCI-CTC).</p><p><b>RESULTS</b>The children carrying MTHFR 1298AC had a higher risk of developing thrombocytopenia compared with the carriers of the 1298 AA genotype (OR=13.7, 95%CI=1.18-159.36, P=0.036). There was no significant difference in HD-MTX chemotherapy-related adverse effects between the patients with different MTHFR C677T or G1793A genotypes.</p><p><b>CONCLUSIONS</b>MTHFR A1298C polymorohism may associate with the toxicity of HD-MTX chemotherapy in children with ALL.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Metotrexato
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Tratamento Farmacológico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Genética
/
Genótipo
/
Antimetabólitos Antineoplásicos
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2013
Tipo de documento:
Article