Molecular cytogenetic characteristics of chronic lymphocytic leukemia / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 349-352, 2006.
Article
em Zh
| WPRIM
| ID: wpr-236968
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular cytogenetic characteristics in patients with chronic lymphocytic leukemia (CLL).</p><p><b>METHODS</b>Interphase fluorescence in situ hybridization (FISH) was used to detect trisomy 12, deletion of 13q14 and 17p13 in 60 patients with CLL.</p><p><b>RESULTS</b>Out of the 60 patients, 41 (68.3%) had at least one kind of molecular cytogenetic aberrations. Two (3.3%) had two kinds of abnormalities. Trisomy 12 was found in 12 (20.0%) cases, 13q14 deletion in 24 (40.0%) cases and 17p13 deletion in 5 (11.7%) cases. The number of trisomy 12 cells ranged from 4.0% to 34.0%, 13q14 deletion ranged from 22.0% to 93.0% and 17p13 deletion ranged from 6.0% to 68.0%. There was no significant difference among each Binet stages.</p><p><b>CONCLUSION</b>FISH is a more rapid, accurate and sensitive technique in analysis of chromosome aberrations in CLL. FISH may provide accurate information of molecular cytogenetics for CLL.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Trissomia
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Cromossomos Humanos Par 12
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Cromossomos Humanos Par 13
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Cromossomos Humanos Par 17
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Leucemia Linfocítica Crônica de Células B
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Deleção Cromossômica
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Hibridização in Situ Fluorescente
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Genética
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2006
Tipo de documento:
Article