Taxol-producing fungi: a new approach to industrial production of taxol / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-6, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-237032
ABSTRACT
Produced by and purified from Taxus brevifolia, Taxol (paclitaxel) has become a widely used cancer drug in clinic. Due to the rapid growing market, current industrial production of taxol by semi-synthesis that consumes large amount of Taxus trees cannot meet the requirement of the market. The discovery of taxol-producing fungus Taxomyces andeanae, an endophyte of T. brevifolia, by Stierle et al (1993), paves a new way to the production of the drug, i.e. employing large-scale fungal fermentation to make Taxol at lower cost and yet higher yield. This review discusses the present problems in taxol production in pharmaceutical industry, the finding and research progress on taxol-producing fungi, and the potential application of fungal fermentation to manufacture this important drug.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tecnologia Farmacêutica
/
Paclitaxel
/
Taxus
/
Fungos Mitospóricos
/
Fermentação
/
Metabolismo
/
Métodos
/
Microbiologia
/
Antineoplásicos Fitogênicos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS