ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus / 당뇨병
Korean Diabetes Journal
;
: 320-326, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-23769
ABSTRACT
BACKGROUND:
Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients.METHODS:
The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified.RESULTS:
The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959).CONCLUSIONS:
The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pirofosfatases
/
Doenças Cardiovasculares
/
Cálcio
/
Prevalência
/
Remoção
/
Diester Fosfórico Hidrolases
/
Difosfatos
/
Vasos Coronários
/
Diabetes Mellitus Tipo 2
/
Genótipo
Tipo de estudo:
Estudo de prevalência
/
Estudo prognóstico
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Korean Diabetes Journal
Ano de publicação:
2010
Tipo de documento:
Artigo
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