Formula Optimization in Renshen Jianxin Capsule Based on Uniform Design and Anti-myocardial Ischemia Effect / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 1105-1108, 2015.
Article
em Zh
| WPRIM
| ID: wpr-237892
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To realize quadratic formula optimization of Renshen Jianxin Capsule (RJC) by screening Chinese herbs with major anti-myocardial ischemia effect in RJC and optimize their optimal dosages.</p><p><b>METHODS</b>By following "uniform design-pharmacodynamic experiment-mathematical modeling-formula optimization", authors employed U10(10(8)) uniform design in the experiment. Eight Chinese herbs contained in RJC were taken as observatory factors. Electrocardiograph (ECG) changes of myocardial ischemia induced by isoproterenol were taken as pharmacodynamic indices. The mathematical model between herbal factors and pharmacodynamic indices was established using stepwise regression analysis to screen Chinese herbs with major anti-myocardial ischemia effect. Their optimal dosages were optimized using the grid algorithm.</p><p><b>RESULTS</b>The regression equation was y =1. 7889 -0. 3247 Ginseng xSalvia Miltiorrhiza -0. 0663 Astragalus membranaceus xOriental Waterplantain tuber. Forecasting factors included were Ginseng, Salvia Miltiorrhiza, Astragalus membranaceus, and Oriental Waterplantain tuber. The optimal formula dosage calculated by the grid algorithm was Ginseng 1. 62 g, Astragalus membranaceus 4. 62 g, Salvia Miltiorrhiza 2. 43 g, and Oriental Waterplantain tuber 1. 66 g.</p><p><b>CONCLUSION</b>Uniform design combined with stepwise regression analysis and grid algorithm were able to realize quadratic formula optimization of RJC.</p>
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Índice:
WPRIM
Assunto principal:
Farmacologia
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Padrões de Referência
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Doença da Artéria Coronariana
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Medicamentos de Ervas Chinesas
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Química Farmacêutica
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Isquemia Miocárdica
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Astragalus propinquus
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Salvia miltiorrhiza
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Usos Terapêuticos
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Tratamento Farmacológico
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2015
Tipo de documento:
Article