Diagnostic value of complexed prostate-specific antigen for prostate cancer / 中华男科学杂志
National Journal of Andrology
; (12): 431-433, 2003.
Article
em Zh
| WPRIM
| ID: wpr-238005
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the clinical value of serum complexed prostate-specific antigen(cPSA) in the diagnosis of prostate cancer (PCa).</p><p><b>METHODS</b>Serum samples were obtained from 110 men with untreated benign prostatic hyperplasia (BPH) and 78 men with untreated PCa. The levels of cPSA, total PSA (tPSA) were determined by autoimmunochemistry luminescence method.</p><p><b>RESULTS</b>Both cPSA and cPSA/tPSA ratio were significantly different between patients with PCa and BPH (P < 0.005), especially, in men with tPSA values between 4.0-10.0 micrograms/L (the diagnostic gray zone). When cPSA/tPSA > or = 0.78 was taken as the cut-off value conjugated with tPSA < or = 10.0 micrograms/L, the sensitivity, specificity, negative predictive value and positive predictive value were as high as 97.8%, 95.8%, 81.9% and 96.5%.</p><p><b>CONCLUSIONS</b>With the introduction of cPSA and cPSA/tPSA ratio, early diagnosis of PCa by the assessment of tPSA has been made more sensitive and reliable, especially when the tPSA is within the diagnostic gray zone.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Hiperplasia Prostática
/
Neoplasias da Próstata
/
Sangue
/
Antígeno Prostático Específico
/
Diagnóstico
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2003
Tipo de documento:
Article