Leydig cell apoptosis and its regulation / 中华男科学杂志
National Journal of Andrology
;
(12): 218-225, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-238059
ABSTRACT
Apoptosis is necessary for the development and maturation of Leydig cells. However, increased apoptosis results the decline of testosterone production, which may increase germ cell apoptosis and the possibility of infertility. There are several aspects contributing to Leydig cell apoptosis such as ethane dimethanesulphonate (EDS), glucocorticoid, developmental stage and some hormones including FSH, LH/hCG and testosterone. A number of genes are involved in the regulation of Leydig cells apoptosis. It was reported that SCF/c-kit, Bcl-2 and Bcl-xl inhibited the apoptosis while caspase-3, Fas, Bax and clusterine stimulated it.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Apoptose
/
Fator de Células-Tronco
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Caspases
/
Biologia Celular
/
Proteína bcl-X
/
Caspase 3
/
Células Intersticiais do Testículo
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2003
Tipo de documento:
Artigo
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