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Autoantibodies against alpha1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 602-604, 2006.
Artigo em Chinês | WPRIM | ID: wpr-238554
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of autoantibodies against alpha(-) adrenergic receptor on cardiac remodeling in patients with hypertension.</p><p><b>METHODS</b>Five hundred and fifty three patients with hypertension in our hospital were selected. The autoantibodies against alpha(1) adrenergic receptor in sera of donor were detected by ELISA, and the results of echocardiography were recorded. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension.</p><p><b>RESULTS</b>The percentage of autoantibodies against alpha(1) adrenergic receptor positive was 32.3% (179/553). There were significant difference between the positive group and negative group on the ratio of left atrial enlargement (53.6%, 44.3%, respectively; P < 0.05) and left ventricular enlargement (12.8%, 6.1%, respectively; P < 0.01). The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate (HR) and autoantibodies against alpha(1) adrenergic receptor in the serum (all P < 0.05).</p><p><b>CONCLUSIONS</b>The autoantibodies against alpha(1) adrenergic receptor have a relationship with left ventricular enlargement of hypertension. Patients with the activity of autoantibodies against alpha(1) adrenergic might contribute to predict cardiac remodeling.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Autoanticorpos / Sangue / Ensaio de Imunoadsorção Enzimática / Modelos Logísticos / Receptores Adrenérgicos alfa 1 / Remodelação Ventricular / Alergia e Imunologia / Hipertensão Tipo de estudo: Estudo prognóstico / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Cardiology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Autoanticorpos / Sangue / Ensaio de Imunoadsorção Enzimática / Modelos Logísticos / Receptores Adrenérgicos alfa 1 / Remodelação Ventricular / Alergia e Imunologia / Hipertensão Tipo de estudo: Estudo prognóstico / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Cardiology Ano de publicação: 2006 Tipo de documento: Artigo