Study on bioequivalence of new Wubei fast-release tablet / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2728-2732, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-238654
ABSTRACT
<p><b>OBJECTIVE</b>To prepare a new Wubei fast-release tablet and study the pharmacokinetics and bioequivalence of self-prepared Wubei fast-release tablet and Wubei powder in Beagle dogs.</p><p><b>METHOD</b>Wubei fast-release tablet was prepared with direct powder compression. Six Beagle dogs were randomly devided into two groups. They were orally administered with Wubei fast-release tablet and Wubei powder, respectively. Peimine concentrations in human plasma were determined by HPLC-MS/MS after administration. The pharmacokinetic parameters were calculated by DAS 2.0 using a non-compartmental analysis. The bioequivalence of fast-release tablet and powder was evaluated.</p><p><b>RESULT</b>The main pharmacokinetic parameters of peimine in Wubei fast-release tablet as follows Cmax (7.4 +/- 2.3) microg x L(-1), AUC(0-t) (59.13 +/- 15.25) microg x L(-1) x h(-1), Tmax (1.5 +/- 0.0) h. The main pharmacokinetic parameters of peimine in Wubei powder as follows Cmax (8.0 +/- 1.7) microg x L(-1), AUC(0-t) (68.78 +/- 16.27) microg x L(-1) x h(-1), Tmax (1.5 +/- 0.0) h. The 90% confidence interval of InAUC(0-t), and lnCmax of peimine in Wubei fast-release tablet were 95.4% - 104.6%, 90.9% - 109.1% of corresponding parameters of Wubei powder, respectively.</p><p><b>CONCLUSION</b>The self-prepared Wubei fast-release tablet and Wubei powder were bioequivalent. And the self-prepared Wubei fast-release tablet had simple production process, easy administration.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Comprimidos
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Equivalência Terapêutica
/
Química
/
Sistemas de Liberação de Medicamentos
/
Bicarbonato de Sódio
/
Estabilidade de Medicamentos
/
Metabolismo
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Artigo
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