Sperm DNA damage in young men working on the plateau / 中华男科学杂志
National Journal of Andrology
;
(12): 239-242, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-238990
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether long working in the high-altitude area can damage sperm DNA in men.</p><p><b>METHODS</b>We enlisted 51 service men stationed on the plateau in an observation group and another 53 living in the low-altitude area in a control group. We detected and compared the damages to sperm DNA in the semen samples from the two groups using single cell gel electrophoresis and the sperm chromatin dispersion test.</p><p><b>RESULTS</b>The percentages of total, G1, G2 and G3 comet cells and abnormal sperm of the observation group were (5.56 +/- 3.98)%, (3.72 +/- 1.85)%, (1.57 +/- 1.07)%, (0.27 +/- 0.34)% and (16.59 +/- 12.07)%, respectively, before stationed on the plateau, but significantly increased at 6 months of plateau life ([11.15 +/- 8.59]%, [5.97 +/- 3.26]%, [3.83 +/- 2.13%, [1.35 +/- 1.53]% and [22.03 +/- 15.33]%, P<0.05). The percentages of G2 comet cells and abnormal sperm were decreased to (3.32 +/- 1.83)% and (20.54 +/- 15.52)% at 12 months, but still significantly higher than the baseline (P<0.05).</p><p><b>CONCLUSION</b>Long working on the plateau may damage sperm DNA, but its influence on male fertility deserves further investigation. Therefore, it is important to reinforce reproductive health protection for males working on the plateau.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Contagem de Espermatozoides
/
Espermatozoides
/
Dano ao DNA
/
Ensaio Cometa
/
Altitude
/
Metabolismo
Limite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2012
Tipo de documento:
Artigo
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