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Big data: the progress and applications of antibody repertoire sequencing / 南方医科大学学报
Journal of Southern Medical University ; (12): 463-467, 2015.
Artigo em Chinês | WPRIM | ID: wpr-239155
ABSTRACT
Antibody, the major effector in adaptive immunity, plays key roles in protective and pathogenic immune responses. Integrative analyses of antibody development, differentiation, and maturation promote the research in immune mechanism, vaccine design, and therapies for autoimmune disorders. The development of next generation sequencing technologies has enabled large-scale characterization of functional antibody repertoires. With the advantages of next generation sequencing, antibody and antibody repertoire analysis have been successfully used in identification of HIV-1-broadly neutralizing antibodies, design of rationale structure-based vaccine, and development of immunology. With increasing sequence length and precision, improvement of experimental protocols and bioinformatics analyses, and development of single cell sequencing technology, antibody repertoire sequencing will expedite the research in antibody-related immune response, and thus facilitates vaccine design for infectious diseases, clinical diagnosis and interference of autoimmune diseases. This review introduces the technologies, progresses, applications, and caveats of antibody repertoire sequencing.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vacinas / Química / HIV-1 / Anticorpos Neutralizantes / Sequenciamento de Nucleotídeos em Larga Escala / Anticorpos / Formação de Anticorpos Tipo de estudo: Guia de Prática Clínica Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vacinas / Química / HIV-1 / Anticorpos Neutralizantes / Sequenciamento de Nucleotídeos em Larga Escala / Anticorpos / Formação de Anticorpos Tipo de estudo: Guia de Prática Clínica Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2015 Tipo de documento: Artigo