Tripartite-motif protein 25 and pyruvate kinase M2 protein expression in non-small cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 437-441, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-239161
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of tripartite-motif protein 25 (TRIM25) and pyruvate kinase M2 (PKM2) protein in non-small cell lung cancer (NSCLC) and explore their role in the occurrence and progression of NSCLC.</p><p><b>METHODS</b>The expressions of TRIM25 and PKM2 protein were detected in 60 NSCLC specimens and 20 adjacent normal lung tissue (>5 cm from the lesions) with immunofluorescence histochemical method and in 10 fresh specimens of NSCLC with Western blotting. The results were analyzed in relation with the clinicopathological features of the patients.</p><p><b>RESULTS</b>The positivity rates of TRIM25 expression was 45% in the 60 lung carcinoma specimens, significantly higher than that in the 20 normal lung tissues (10%, P=0.005). TRIM25 protein was expressed in 28.6% of lung adenocarcinoma tissues and in 59.4% of squamous carcinoma tissues (P=0.017). TRIM25 protein expression was positively correlated with the TNM stages and lymph node metastasis of NSCLC (P<0.05). The expressions of PKM2 protein in 60 cases of lung carcinoma was 73.3%,while in 20 cases of normal lung tissues the expressions was 30%(P=0.001). The positivity rates of PKM2 expression differed significantly between lung adenocarcinoma and squamous carcinoma (57.1% vs 87.5%, P=0.008). An inverse correlation was noted between TRIM25 and PKM2 expressions (P=0.026).</p><p><b>CONCLUSION</b>TRIM25 and PKM2 protein may participate in the occurrence and progression of NSCLC, and their expressions are inversely correlated.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Hormônios Tireóideos
/
Fatores de Transcrição
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Proteínas de Transporte
/
Carcinoma Pulmonar de Células não Pequenas
/
Ubiquitina-Proteína Ligases
/
Proteínas com Motivo Tripartido
/
Pulmão
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2015
Tipo de documento:
Artigo
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