Association of NEDD4 gene polymorphisms with schizophrenia and its clinical characteristics in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 385-390, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-239463
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of neural precursor cell expressed developmentally down-regulated 4 (NEDD4) with schizophrenia.</p><p><b>METHODS</b>Five single nucleotide polymorphisms (SNPs) of the NEDD4 gene were genotyped by TaqMan SNP genotyping assay in an independent sample of 464 individuals with schizophrenia and 487 healthy controls from eastern Han Chinese population. Clinical data were collected with a general information questionnaire and Positive and Negative Syndrome Scale (PANSS).</p><p><b>RESULTS</b>Frequencies of rs3088077 (allelic χ2=18.024, P=0.000; genotypic χ2=16.634, P=0.000), rs7162435 (allelic χ2=6.771, P=0.009; genotypic χ2=7.352, P=0.025) and rs2303579 (allelic χ2=11.253, P=0.001; genotypic χ2=12.248, P=0.002) were found to be significant different between the two groups. Moreover, TT of rs7162435 was significantly correlated with scores of factors of excitement and hostility (14.53±3.925, F=3.551, P=0.029).</p><p><b>CONCLUSION</b>rs3088077, rs7162435 and rs2303579 of the NEDD4 gene may be associated with schizophrenia. Moreover, the TT genotype of rs7162435 may increase the severity of excitement and hostility. Our results may provide a clue for delineating the connection between the glutamate hypothesis of schizophrenia and ubiquitination.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquizofrenia
/
China
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Ubiquitina-Proteína Ligases
/
Povo Asiático
/
Alelos
/
Etnologia
/
Complexos Endossomais de Distribuição Requeridos para Transporte
/
Ubiquitina-Proteína Ligases Nedd4
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2015
Tipo de documento:
Artigo
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