Progress on the role of Toll-like receptors ininfections / 浙江大学学报·医学版

ABSTRACT

Toll like receptors (TLRs) are expressed mainly on innate immunocytes such as dendritic cells and macrophages, and may have the potential to recognize and bind to pathogen-associated molecular patterns (PAMPs) from, thereby triggering the downstream signals. The genetic polymorphism of TLRs is associated with susceptibility to. The activation of TLRs by PAMPs fromcan induce the production of proinflammatory cytokines that play key roles in the anti-infection of. However, in order to evade the immune response of host,can also change its bacterial phase. Understanding of the interaction between TLRs andwill provide novel evidence to further clarify the mechanisms of anti-fungal immune response.