Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1328-1331, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-239692
ABSTRACT
<p><b>OBJECTIVE</b>To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.</p><p><b>METHOD</b>Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum.</p><p><b>RESULT</b>Inclusion ratio of CT versus HPCD was 11. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug.</p><p><b>CONCLUSION</b>Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenantrenos
/
Solubilidade
/
Fatores de Tempo
/
Portadores de Fármacos
/
Medicamentos de Ervas Chinesas
/
Disponibilidade Biológica
/
Química
/
Tecnologia Farmacêutica
/
Salvia miltiorrhiza
/
Beta-Ciclodextrinas
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Artigo
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