Effect of Shuanghuang Shengbai granule on radiotherapy or chemotherapy induced leukopenia in mice / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of Shuanghuang Shengbai granule on mice leukopenia induced by ip cyclophosphamide (CTX) or radiation.</p><p><b>METHOD</b>Mice leukopenia models were induced by ip CTX or radiation, and then treated with Shuanghuang Shengbai granule per oral. The peripheral hemogram, thymus index, spleen index, bone marrow nucleated cell (BMNC) and colony forming unit-spleen (CFU-S) were detected. The bone marrow cell differentiation was examined. The pathological slices of bone marrow were observed.</p><p><b>RESULT</b>Shuanghuang Shengbai granule could increase the WBC, BMNC, CFU-S of model mice significantly; Shuanghuang Shengbai granule could make the granulocyte and erythrocyte index recovered to normal level and it could also protect the bone marrow hemotopoietic microenvironment from the harm of radiation.</p><p><b>CONCLUSION</b>Shuanghuang Shengbai granule has apparent leukogenic function.</p>