The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1154-1156, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-239730
ABSTRACT
<p><b>OBJECTIVE</b>To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.</p><p><b>METHOD</b>Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.</p><p><b>RESULTS</b>The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).</p><p><b>CONCLUSION</b>HPCD is an ideal solubilizer for paeonolum.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acetofenonas
/
Plantas Medicinais
/
Solubilidade
/
Química
/
Paeonia
/
Beta-Ciclodextrinas
/
Estabilidade de Medicamentos
/
Excipientes
/
2-Hidroxipropil-beta-Ciclodextrina
/
Concentração de Íons de Hidrogênio
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Artigo
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