Study of the correlation between the expression level of asparagine synthetase and the outcome of children with acute lymphocytic leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 446-449, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-239999
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether the high level of asparagine synthetase (AS) expression in childhood acute lymphocytic leukemia (ALL) is associated with an inferior prognosis.</p><p><b>METHODS</b>AS mRNA level in leukemic cells from 53 newly diagnosed ALL children was measured by real time fluorescent quantitative PCR method. Patients were divided into groups according to their relapse risk and outcome, and the AS expression levels in each group were compared. The survival rates in different AS expressing level groups were estimated and compared.</p><p><b>RESULTS</b>The highest level of AS [median 17.25 (2.48-46. 82)] was observed in children failed remission, intermediate level [14.28 (3.20-54.47)] in relapsed children and the lowest level [5.08 (0.84-54.92)] in children with continuous complete remission (CCR) (P<0.05). The AS mRNA level [14.93 (2.48-54.47)] in children with poor outcome (un-remission and relapsed) was significantly higher than that in children in CCR (P<0.01). The two-year estimated disease free survival was much lower in children with high AS expression (53.8%) than in those with low AS expression (84.6%) (P<0.05).</p><p><b>CONCLUSION</b>High expression of AS is associated with a poor outcome in ALL children.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Aspartato-Amônia Ligase
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2008
Tipo de documento:
Artigo
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