The clinical and laboratory features of 263 cases of chronic lymphocytic leukemia / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the clinical and laboratory features of chronic lymphocytic leukemia (CLL).</p><p><b>METHODS</b>Retrospective investigation of 263 patients with CLL in our hospital between Feb. 2000 and Jan. 2007.</p><p><b>RESULTS</b>The median age was 60 years with male/female ratio of 2.17 1. Patients who were asymptomatic at diagnosis (35.4%) had low Rai grades. Fatigue and lymphadenopathy (54.8%) were the most common features at presentation. Infections, connective tissue diseases and secondary tumors frequently occurred in CLL. WBC counts were between (10 - 100) x 10(9)/L, with lymphocytes percentages more than 0.50 in 97.1% patients. Bone marrow was normal- to hyper-cellularity with lymphocytes percentages more than 0.300 in 99.4% patients. Diffuse infiltrations in bone marrow section were found in 72.2% patients. There were lower CD5 (85.1%) and higher CD25 (78.9%) positivities in the present series as compared with that in other reports. Hypogammaglobulinemia, especially hypo-IgM, usually occurred. Chromosome abnormality were rarely found by routine chromosome examination.</p><p><b>CONCLUSIONS</b>There were some clinical and laboratory characteristics different from that of abroad data. Further exploration of new markers is required for prognosis prediction and treatment choice.</p>