The expression and role of Fas/FasL in infantile hemangioma / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 116-120, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-240372
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of Fas/FasL in infantile hemangiomas and discuss the role of Fas/FasL in the pathologic evolution of infantile hemangioma.</p><p><b>METHOD</b>The EnVision immunohistochemical stain and RT-PCR technique was used to examine the expression of Fas/FasL protein and mRNA in the infantile hemangiomas.</p><p><b>RESULTS</b>(1) In the early and middle proliferating stage, a number of infantile hemangioma cells expressed Fas. In the late proliferating stage, the number of positive cells increased obviously and the expression of Fas mRNA was reaching the strongest level. In the early regressing stage the Fas still existed in some cells and after that the expression decreased quickly. (2) Up to the middle proliferating stage, there were a few of FasL(+) cells foound. In the late proliferating stage, the number of FasL(+) cells increased significantly. From the early regressing stage, the number of FasL(+) cells decreased rapidly and disappeared.</p><p><b>CONCLUSION</b>There may exist significant correlation between the expression of Fas/FasL and the development of the infantile hemangioma cells. The apoptosis of the infantile hemangioma cells mediated by Fas/ FasL may be the major reason of the spontaneous involution of infantile hemangioma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
RNA Mensageiro
/
Transdução de Sinais
/
Apoptose
/
Receptor fas
/
Proteína Ligante Fas
/
Hemangioma
/
Hiperplasia
/
Metabolismo
Limite:
Criança
/
Criança, pré-escolar
/
Humanos
/
Lactente
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2006
Tipo de documento:
Artigo
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