The experimental study of mechanism of integrin in hypertrophic scar contracture / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 38-40, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-240390
ABSTRACT
<p><b>OBJECTIVE</b>To study the mechanism of integrin in hypertrophic scar.</p><p><b>METHODS</b>Fibroblasts from 10 samples of human hypertrophic scars was cultured, FQ-PCR assay was applied to detect mRNA expression of alpha-SMA in hypertrophic scar fibroblasts after integrin and FAK antibody blocking.</p><p><b>RESULTS</b>mRNA of alpha-SMA in fibroblasts expressed obviously lower after integrin and FAK antibody blocking than that of control groups ( P < 0.05).</p><p><b>CONCLUSION</b>Through accelerating the synthesis of alpha-SMA, integrin and FAK play an important role in contracture of hypertrophic scar.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
RNA Mensageiro
/
Integrinas
/
Células Cultivadas
/
Actinas
/
Cicatriz Hipertrófica
/
Contratura
/
Quinase 1 de Adesão Focal
/
Fibroblastos
/
Metabolismo
Limite:
Adulto
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2006
Tipo de documento:
Artigo
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