Expression and significance of TRAIL receptors in fibroblasts of hypertrophic scar / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 444-447, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-240405
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of TRAIL receptors in fibroblasts of hypertrophic scar in the proliferative stage and explore its significance.</p><p><b>METHODS</b>30 samples of hypertrophic scar were taken from 30 burn cases in the proliferative stage. 30 samples of normal skin were taken as the control. The expressions of TRAIL receptors in the fibroblasts of hypertrophic burn scar and the normal skin were assayed by semiquantitative RT-PCR and flowcytometry.</p><p><b>RESULTS</b>The expression level of DR5 in the fibroblasts of hypertrophic burn scar is much lower than the control (P < 0.05); the expression level of DcR1 in the fibroblasts of hypertrophic burn scar is much higher than the control (P < 0.05).</p><p><b>CONCLUSIONS</b>The down-regulated DR5 expression and elevated DcR1 expressions in the fibroblasts of hypertrophic burn scar may attribute to the apoptosis change induced by TRAIL and explain the apoptosis differences between the fibroblasts of hypertrophic scar and normal skin to a certain extent.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Queimaduras
/
Cicatriz Hipertrófica
/
Apoptose
/
Receptores do Ligante Indutor de Apoptose Relacionado a TNF
/
Fibroblastos
/
Metabolismo
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2005
Tipo de documento:
Artigo
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