Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 13-15, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-240525
ABSTRACT
<p><b>OBJECTIVE</b>To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.</p><p><b>METHODS</b>RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.</p><p><b>RESULTS</b>Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.</p><p><b>CONCLUSION</b>Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Doadores de Sangue
/
RNA Viral
/
Doença Aguda
/
Vírus da Hepatite E
/
Hepatite E
/
Reação Transfusional
/
Macaca mulatta
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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