Experimental studies on imaging of infected site with (99m)Tc-labeled ciprofloxacin in mice / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1907-1909, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-240773
ABSTRACT
<p><b>BACKGROUND</b>Bacterial infection can pose a substantial diagnostic dilemma. (99m)Tc-labeled ciprofloxacin (CPF) was developed as a biologically active radiopharmaceutical to diagnose infection. In the present research, we studied the biodistribution and imaging properties of infection tracer (99m)Tc-CPF in a mouse model of infection.</p><p><b>METHODS</b>CPF was labeled with (99m)Tc and the radiochemical purity and labeling rate were measured. A mouse model of infection was established. We then determined the biodistribution of (99m)Tc-CPF and conducted the whole body scintigraphy of the animal model.</p><p><b>RESULTS</b>(99m)Tc-Ciprotech was stable for at least 6 hours at room temperature. The labeling rate of CPF by (99m)Tc was over 90%. Clearance of radioactivity mainly occurred in the liver and kidney, and the clearance from blood was rapid. Both biodistribution and imaging results showed higher uptake of (99m)Tc-CPF at sites of infection. The infectious tissue/normal tissue ratio peak was 4.30 at 4 hours after injection.</p><p><b>CONCLUSIONS</b>(99m)Tc-CPF is a sensitive radiopharmaceutical for scintigraphy of infectious lesions and it is easy to prepare.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infecções Bacterianas
/
Farmacocinética
/
Distribuição Tecidual
/
Ciprofloxacina
/
Compostos de Organotecnécio
/
Química
/
Diagnóstico
/
Modelos Animais de Doenças
/
Marcação por Isótopo
/
Métodos
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2009
Tipo de documento:
Artigo
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