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Therapeutic effect of qingyi decoction and tetrandrine in treating severe acute pancreatitis in miniature pigs and serum drug level determination / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 832-836, 2003.
Artigo em Chinês | WPRIM | ID: wpr-240848
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the therapeutic effect of Qingyi Decoction (QYD) and tetrandrine (Tet), used singly or combind, in treating miniature pigs with severe acute pancreatitis (SAP) and its mechanism.</p><p><b>METHODS</b>Thirty-two Guizhou miniature pigs were made into SAP model by pancreatic duct retrograde injection of 5% sodium taurocholate. They were randomly divided into 4 groups the control group, the QYD group, the Tet group and the combined treated group. The serum amylase activity and interleukin-1 and 6 (IL-1, IL-6) contents in serum from vena cava and portal vein were tested by biochemistry and radioimmunoassay (RIA). Serum emodin and plasma Tet levels were measured by high performance liquid chromatography (HPLC) 24, 48 and 72 hrs after treatment. And the pathological changes of pancreas, lung and liver were observed under microscope.</p><p><b>RESULTS</b>The mortality of SAP pigs was reduced significantly and the inflammatory injury of the organs was ameliorated obviously in all treated groups, and the increased amylase activity and IL-1, IL-6 levels was attenuated. The therapeutic effect was much more obvious, and the plasma Tet level at different time points were much higher in the combined treated group than those in the other two groups treated by single drug (P < 0.01).</p><p><b>CONCLUSION</b>Both QYD and Tet could treat effectively SAP through multiple pathways, combination of them reveals an elevation of serum drug concentration and shows a synergistic effect.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Porco Miniatura / Sangue / Medicamentos de Ervas Chinesas / Farmacocinética / Distribuição Aleatória / Emodina / Interleucina-6 / Interleucina-1 / Pancreatite Necrosante Aguda / Benzilisoquinolinas Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Porco Miniatura / Sangue / Medicamentos de Ervas Chinesas / Farmacocinética / Distribuição Aleatória / Emodina / Interleucina-6 / Interleucina-1 / Pancreatite Necrosante Aguda / Benzilisoquinolinas Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2003 Tipo de documento: Artigo