Effects of langchuangjing granule on apoptotic of CD4+ T and CD19+ B in spleen of BXSB mice with systemic lupus erythematosus / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect on apoptotic of CD4+ T, CD19+ B in spleen of BXSB mice with systemic lupus erythematosus treated with Langchuangjing Granule and to probe into the mechanism of treatment.</p><p><b>METHODS</b>The apoptosis was examined by the flow cytometric analysis and immunofluorescence double-staining method.</p><p><b>RESULTS</b>Apoptosis of male BXSB mice speeds up. Langchuangjing Granule can restrain the excessive apoptosis of CD4+ T and CD19+ B cells in spleen.</p><p><b>CONCLUSION</b>Langchuangjing Granule treated systemic lupus erythematosus by restraining the excessive apoptotic of T, B lymphocytes, probably restraining the release of excessive amount of apoptotic DNA fragments, so decreasing abnormal proliferation of B cells and the produce of autoantibodies.</p>