Effect of pingchuan mixture on eosinophil cation protein and interleukin-5 in experimental guinea pigs with asthma / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of Pingchuan Mixture (PCM) on plasma eosinophil cation protein (ECP), interleukin-5 in bronchial alveolar lavage fluid (BALF) and inflammatory cell count in experimental guinea pigs with asthma.</p><p><b>METHODS</b>The eosinophil, neutrophil, lymphocyte count were conducted by conventional method, IL-5 was detected by ELISA and ECP determined by RIA.</p><p><b>RESULTS</b>Levels of eosinophil, neutrophil, lymphocyte, ECP and IL-5 after treatment were significantly lower than those before treatment, the difference between groups treated respectively by PCM, aminophylline, dexamethasone and Dingchuan Zhike Tablet was insignificant.</p><p><b>CONCLUSION</b>PCM could treat asthma by reducing the inflammatory cell count, ECP and IL-5.</p>