Research on regulation mechanism of osteoclast differentiation / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 580-584, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-240988
ABSTRACT
Osteoclasts are multinucleated giant cell, which derived from mononuclear myeloid hematopoietic stem cells with the function of bone absorption. Osteoclasts plays a key role in bone metabolism, therefore the body is very strict to regulation of osteoclastogenesis. Mobilization and differentiation of osteoclast maturation is a complex and sophisticated multi-level regulatory processes. In the relevant regulatory mechanisms, OPG/RANKL/RANK system plays a pivotal role in the process of osteoclast differentiation and maturation. Recent studies revealed that immune cells and osteoclasts were closely connect with each other in the field of bone metabolism, also provide a new therapeutic target for the treatment of bone diseases. The apoptosis of osteoclasts in bone metabolism have been payed more attention,while its mechanism is still not clear, which need further research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoclastos
/
Diferenciação Celular
/
Regulação da Expressão Gênica
/
Biologia Celular
/
Ligante RANK
/
Receptor Ativador de Fator Nuclear kappa-B
/
Osteoprotegerina
/
Genética
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2015
Tipo de documento:
Artigo
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