Indications and clinical outcomes of half-ICSI in 99 cases / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine an optimal insemination technique for patients suspected of high risk of fertilization failure and undergoing assisted reproduction treatment.</p><p><b>METHODS</b>Ninety-nine couples were treated by conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in one cycle (half-ICSI) by dividing the sibling oocytes in halves. The clinical and laboratory data were analyzed, and the rates of fertilization, cleavage, good embryos and clinical pregnancy were compared between different fertilization methods.</p><p><b>RESULTS</b>In the half-ICSI group, the fertilization rate of ICSI (80.5%) was significantly higher than that of IVF (42.9%) (P < 0.01), and so were the rates of complete fertilization failure (21.2%) and low fertilization (16.2%) of IVF than those of ICSI (0 and 3.0%). No significant differences were observed in the rates of cleavage and good-quality embryos between the two groups (P > 0.05).</p><p><b>CONCLUSION</b>ICSI can help to avoid complete fertilization failure, achieve more high quality embryos for transfer and improve the rate of pregnancy for patients with high risk of fertilization failure.</p>