Excretion of beta-elemene from rat respiratory tracts / 药学学报

ABSTRACT

<p><b>AIM</b>To investigate the excretion of beta-elemene from the respiratory tracts in male Spraque-Dawley rats.</p><p><b>METHODS</b>After a single administration of beta-elemene to rats at the dosage of 75 mg x kg(-1) (i.v. or i.p.), the exhaled gases were collected and concentrated at various time points. The residues were analyzed by gas chromatography.</p><p><b>RESULTS</b>A minor amount of unchanged beta-elemene was excreted via rat respiratory tracts after iv and ip administration of a single dose. The cumulative excretion were 1.41% and 0.51% respectively.</p><p><b>CONCLUSION</b>The results demonstrated that unchanged beta-elemene excretes from rat respiratory tracts, but may not be the main elimination pathway in rats.</p>