Pharmacokinetics and distribution of superoxide dismutase liposomes in rats / 药学学报

ABSTRACT

<p><b>AIM</b>To evaluate the effects of surfactants on the pharmacokinetics and distribution in rats after intravenous administration of SOD liposomes.</p><p><b>METHODS</b>The liposomes were prepared by reverse phase evaporation method. The activity of SOD was assayed by method of xanthine oxidase.</p><p><b>RESULTS</b>The T1/2 of SOD solution, common SOD liposome, SOD liposomes modified by DSPE-PEG2000 and Tween 80 were 0.25, 0.34, 0.66 and 0.41 h, respectively; AUC were 12.48, 24.66, 41.16 and 33.02 microg x h x mL(-1), respectively. Compared with the common liposome, the liposomes modified by DSPE-PEG and Tween 80 decreased the content of SOD in liver and spleen, but increased in brain.</p><p><b>CONCLUSION</b>The three kinds of liposomes could increase T1/2 and AUC in some extent, especially in PEG-L group. Tween-L could increase the SOD content in brain, and PEG-L could decrease the SOD content in the liver and spleen compared with the common liposome.</p>