Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists / 药学学报
Acta Pharmaceutica Sinica
; (12): 136-140, 2005.
Article
em Zh
| WPRIM
| ID: wpr-241360
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To find new peroxisome proliferator-activated y agonists with high activity and low toxicity.</p><p><b>METHODS</b>Based on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated.</p><p><b>RESULTS</b>Eight new compounds were obtained. The structures of synthesized compounds were characterized by NMR, MS and IR. Four compounds (1A-4A) showed insulin-sensitizing activities.</p><p><b>CONCLUSION</b>Compounds (1A and 3A) showed excellent insulin-sensitizing activities and should be worth further investigation.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
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Células 3T3-L1
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PPAR gama
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Glucose
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Hipoglicemiantes
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Insulina
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Isoxazóis
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article