Flow injection chemiluminescent detection of acemetacin in KMnO4 - Na2 SO3 system / 药学学报
Acta Pharmaceutica Sinica
;
(12): 925-928, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-241409
ABSTRACT
<p><b>AIM</b>To study the sensitizing effect of acemetacin (ACE) on the weak chemiluminescent (CL) reaction of KMnO4 with sulfite and establish a fast and convenient method for CL detection of ACE.</p><p><b>METHODS</b>Using the sensitizing effect of ACE on KMnO4-Na2SO3 system and flow injection technique to determine the concentration of ACE.</p><p><b>RESULTS</b>Under optimal conditions, the CL intensity of 1.0 x 10(-2) mol x L(-1) H3PO4 - 5.0 x 10(-5) mol x L(-1) KMnO4 - 4.0 x 10(-4) mol x L(-1) Na2SO3 was proportional to the concentration of ACE ranging from 1.0 x 10(-7) to 1.0 x 10(-5) mol x L(-1). The detection limit of ACE was 6.9 x 10(-8) mol x L(-1) at 3sigma. Satisfactory results were obtained for determination of ACE at 2.5 x 10(-6) mol x L(-1).</p><p><b>CONCLUSION</b>The present method showed good precision, high sensitivity and selectivity and could be used for fast and convenient detection of ACE. It would be of significance to the clinical and pharmacological study of acemetacin.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permanganato de Potássio
/
Sulfitos
/
Química
/
Indometacina
/
Análise de Injeção de Fluxo
/
Medições Luminescentes
/
Métodos
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo
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