Isolation and structure identification of C-25 epimers of inokosterone from Achyranthes bidentata Blume / 药学学报

ABSTRACT

<p><b>AIM</b>To isolate C-25 epimers of inokosterone from Achyranthes bidentata Blume. and identify their structures.</p><p><b>METHODS</b>To separate C-25 epimers of inokosterone by using various kinds of chromatography methods and identify their structures on basis of spectral analysis and chemical method.</p><p><b>RESULTS</b>Three compounds were isolated and their structures were established as 25S-inokosterone (1), 25R-inokosterone (2) and ecdysterone (3).</p><p><b>CONCLUSION</b>Compounds 1 and 2 are new C-25 configuration isomers from Achyranthes bidentata Blume., their absolute configurations are elucidated at the first time, and their 13CNMR data are reported for the first time.</p>