Study on attention-deficit hyperactivity disorder in children based on resting-state functional magnetic resonance imaging / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 723-727, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-241435
ABSTRACT
<p><b>OBJECTIVE</b>To compare resting-state functional magnetic resonance imaging (fMRI) findings of children with attention-deficit hyperactivity disorder (ADHD) and normal children, and to investigate the possible mechanism of brain dysfunction in children with ADHD.</p><p><b>METHODS</b>Resting-state fMRI was performed on 18 children who met the DSM-IV diagnostic criteria for ADHD (ADHD group) and 18 normal children (control group) matched for age, sex, IQ, degree of education and handedness. The two groups were compared in terms of amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo).</p><p><b>RESULTS</b>Compared with the control group, the ADHD group had decreased ALFF in the bilateral posterior lobes of the cerebellum and the left side of the pons, increased ALFF in the right precentral gyrus, decreased ReHo in the left medial frontal gyrus, right superior frontal gyrus, and left precuneus, and increased ReHo in the left anterior lobe of the cerebellum, left caudate nucleus, right parahippocampal gyrus, left precentral gyrus, and right middle frontal gyrus.</p><p><b>CONCLUSIONS</b>In resting state, children with ADHD have decreased brain activity in some regions, including the cerebellum and frontal cortex, compared with normal children, which supports the hypothesis of dysfunctional fronto-cerebellar circuits in ADHD.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
/
Encéfalo
/
Imageamento por Ressonância Magnética
/
Cerebelo
/
Lobo Frontal
/
Métodos
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2013
Tipo de documento:
Artigo
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