Meta-analysis of risk factors for childhood cerebral palsy during pregnancy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 535-540, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-241478
ABSTRACT
<p><b>OBJECTIVE</b>To investigate major risk factors for childhood cerebral palsy (CP) during pregnancy and to provide evidence for the prevention of CP.</p><p><b>METHODS</b>Using the search terms of "cerebral palsy", "pregnancy", "risk factor", and "case-control", a search was performed to collect case-control studies on the risk factors for childhood CP from 1998 to 2011. The obtained data were subjected to metaanalysis using fixed effects model and DersimonionLaird random effects model to quantitatively evaluate risk factors for childhood CP during pregnancy.</p><p><b>RESULTS</b>Eighteen studies involving 11050 cases and 15941 controls were collected. The results of the multivariate analysis for risk factors of childhood CP during pregnancy were as follows maternal age (≥35 years) (OR = 4.172, 95%CI = 1.670-10.426, P < 0.05), multiple pregnancy (OR = 8.402, 95% CI = 2.386-29.584, P < 0.05), medicine use in early pregnancy (OR = 3.974, 95% CI = 2.217-7.123, P < 0.05), harmful environment (OR = 3.299, 95% CI = 1.058-10.289, P < 0.05), recurrent vaginal bleeding during pregnancy (OR = 4.736, 95% CI = 1.792-12.517, P < 0.05), pregnancy infectious diseases (OR = 1.238, 95%CI 0.284-5.395, P > 0.05), pregnancy induced hypertension (OR = 4.096, 95%CI 2.246-7.469, P < 0.05), meat intake (OR = 1.436, 95%CI0.382-5.393, P > 0.05), father smoking (OR = 2.376, 95%CI 0.801-7.049, P > 0.05).</p><p><b>CONCLUSIONS</b>The major risk factors for childhood CP during pregnancy include advanced maternal age (≥35 years), multiple pregnancy, medicine use in early pregnancy, harmful environment, recurrent vaginal bleeding during pregnancy and pregnancy-induced hypertension.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hemorragia Uterina
/
Estudos de Casos e Controles
/
Paralisia Cerebral
/
Fatores de Risco
/
Idade Materna
/
Hipertensão Induzida pela Gravidez
/
Feto
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Limite:
Adulto
/
Criança
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2013
Tipo de documento:
Artigo
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