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Treatment of retinal vein occlusion in rabbits with traditional Chinese medicine Fufang XueShuan Tong / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 3293-3298, 2010.
Artigo em Inglês | WPRIM | ID: wpr-241589
ABSTRACT
<p><b>BACKGROUND</b>Retinal vein occlusion (RVO) is one of the most common causes of visual loss. Many approaches have been tried to treat central retinal vein occlusion (CRVO), and branch retinal vein occlusion (BRVO) with various results. However, there is no defined protocol and limited evidence to support the interventions currently used. The aim of this study was to assess the efficacy of the traditional Chinese medicine Fufang XueShuan Tong (FXST) in treating experimentally created RVO.</p><p><b>METHODS</b>RVO model was first induced in forty-four pigmented rabbits through photocoagulation following injection of rose Bengal. The rabbits were divided into four groups based on the dose of FXST administered (212 mg/kg, 424 mg/kg, 848 mg/kg and control group). The rabbits were observed for four weeks after the procedure, using color fundus photography, fundus fluorescein angiography and electroretinogram examination. Vascular endothelial growth factor (VEGF), interleukin-6 and nitric oxide (NO) levels in the vitreous and histopathologic evaluation were monitored.</p><p><b>RESULTS</b>The obstructed vessels in the treatment groups reopened or anastomosed faster than those in the control group (P < 0.05). The amplitude of maximum b wave and the oscillatory potential were significantly higher in the treatment groups than in the control group (P < 0.01). At both two weeks and four weeks, VEGF and IL-6 levels in the vitreous were significantly decreased in the treatment groups (P < 0.01), while NO levels were significantly elevated (P < 0.01). At the same time, histopathologic evaluation showed different retinal neuroepithelium structures in the different groups. Immunoreactivity of VEGF was greater in the control group than in the treatment groups.</p><p><b>CONCLUSION</b>FXST was helpful in reconstructing retinal vessels in the RVO model, protecting retinal structures and improving visual function, and could inhibit the neovascular factor.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oclusão da Veia Retiniana / Medicamentos de Ervas Chinesas / Interleucina-6 / Fator A de Crescimento do Endotélio Vascular / Usos Terapêuticos / Tratamento Farmacológico / Metabolismo / Óxido Nítrico Tipo de estudo: Guia de Prática Clínica / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oclusão da Veia Retiniana / Medicamentos de Ervas Chinesas / Interleucina-6 / Fator A de Crescimento do Endotélio Vascular / Usos Terapêuticos / Tratamento Farmacológico / Metabolismo / Óxido Nítrico Tipo de estudo: Guia de Prática Clínica / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2010 Tipo de documento: Artigo