Histogenesis of pulmonary sclerosing hemangioma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 239-242, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-241944
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the histogenesis of pulmonary sclerosing hemangioma (PSH).</p><p><b>METHODS</b>Tissue microarray and immunohistochemical technique were used to detect the expression of pan-cytokeratin, epithelial membrane antigen(EMA), vimentin, thyroid transcription factor (TTF)-1, napsin A, synaptophysin, chromogranin A, CD56, E-cadherin, β-catenin, CD117, CD68 and transforming growth factor(TGF)-β1 in 49 cases of PSH.</p><p><b>RESULTS</b>Immunohistochemistry revealed that all cuboidal surface cells expressed pan-cytokeratin, EMA, TTF-1 and napsin A. The polygonal cells expressed EMA, TTF-1, napsin A (positive rate 16.3%, 8/49), but not pan-cytokeratin. Both types of cells were negative for synaptophysin, chromogranin A and CD56. Strong positive staining for E-cadherin and β-catenin appeared on the membrane of cuboidal cells in all PSH, with cytoplasm staining for β-catenin as well. The expression levels of these adhesion molecules decreased in the polygonal cells, with the staining localized to the cytoplasm. E-cadherin staining was not detected or was weak. β-catenin staining was not detected on the cell membrane but partially in the cytoplasm. The polygonal cells stained strongly for vimentin, while only a few cuboidal cells were positive. CD117 and CD68 positive inflammatory cells were scattered between the polygonal cells, which was consistent with the distribution of TGF-β1 positive cells.</p><p><b>CONCLUSIONS</b>PSH originates from the primitive respiratory epithelium, and polygonal stromal cells may be derived from epithelial-mesenchymal transformation of the cuboidal cells. TGF-β1 may play an important role in the formation of sclerosing hemangioma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Pneumonectomia
/
Cirurgia Geral
/
Fatores de Transcrição
/
Vimentina
/
Imuno-Histoquímica
/
Proteínas Nucleares
/
Antígenos de Diferenciação Mielomonocítica
/
Antígenos CD
/
Caderinas
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2012
Tipo de documento:
Artigo
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