Clinicopathologic features of delayed radiation-induced brain injury after radiotherapy for brain tumor / 中华病理学杂志
Chinese Journal of Pathology
; (12): 224-228, 2012.
Article
em Zh
| WPRIM
| ID: wpr-241947
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features of delayed radiation-induced brain injury after radiotherapy for brain tumor.</p><p><b>METHODS</b>The clinical, histopathologic and immunohistochemical features of 9 cases with delayed radiation-induced injury were evaluated.</p><p><b>RESULTS</b>The disease occurred from 6 months to 12 years after radiotherapy and often presented with headache and muscle weakness. Magnetic resonance imaging showed peripheral enhancing lesions with slight mass effect and surrounding edema. Microscopically, the major changes included coagulative necrosis, fibrinoid necrosis of vessels, vascular hyalinization with luminal stenosis and peripheral reactive gliosis. Immunostaining for hypoxia-inducible factors 1α was positive in reactive astrocytes.</p><p><b>CONCLUSIONS</b>Delayed radiation-induced brain injury is a relatively common complication of radiation therapy. The lesion was frequently misdiagnosed as brain tumor. Correct diagnosis relies on clinical, radiologic and pathologic correlation.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Lesões por Radiação
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Radioterapia
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Cirurgia Geral
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Neoplasias Encefálicas
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Diagnóstico por Imagem
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Imageamento por Ressonância Magnética
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Tomografia Computadorizada por Raios X
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Diagnóstico
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Subunidade alfa do Fator 1 Induzível por Hipóxia
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Ano de publicação:
2012
Tipo de documento:
Article