Clinical significance of peripheral blood CD4+CD25+ regulatory T cell in patients with extranodal NK/T cell lymphoma, nasal type / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 808-811, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-242054
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical significance of peripheral blood regulatory T cell (Treg) population in patients with extranodal NK/T cell lymphoma, nasal type (ENKL).</p><p><b>METHODS</b>The peripheral blood CD4+CD25+ Treg cell population was detected by flow cytometry in 41 newly diagnosed ENKL patients between March 2009 and December 2012.</p><p><b>RESULTS</b>The proportion of CD4+CD25+ Treg cell population increased in ENKL patients compared to healthy donors [(9.64±4.96)% vs(7.31±3.02)%, P<0.05], and decreased significantly after treatment [(5.18±2.19)%, P<0.01]. Patients when got response had significantly lower proportion of Treg cells [(8.79±4.15)%] as compared with those without response [(14.57±6.73)%, P<0.05]. The proportion of Treg population was positively related to the serum lactate dehydrogenass level.</p><p><b>CONCLUSION</b>The proportion of peripheral blood Treg cells may be helpful for predicting prognosis and therapeutic efficacy in ENKL patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Linfócitos T CD4-Positivos
/
Linfoma de Células T
/
Linfócitos T CD8-Positivos
/
Diagnóstico
/
Alergia e Imunologia
/
Subunidade alfa de Receptor de Interleucina-2
/
Citometria de Fluxo
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2014
Tipo de documento:
Artigo
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