Chronic lymphocytic leukemia with central nervous system invasion: one case report and literature review / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 592-595, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-242109
ABSTRACT
<p><b>OBJECTIVE</b>To investigate clinical features, diagnosis, therapy, and prognosis in a case of chronic lymphocytic leukemia (CLL) with central nervous system (CNS) invasion.</p><p><b>METHODS</b>The cellular morphology of bone marrow, cytology and flow cytometry of cells in CSF, and radiographic manifestations were detected in a patient diagnosed as CLL with CNS invasion. The clinical features, pathogenesis, diagnosis,therapy, and prognosis of CLL with CNS invasion were reviewed by literatures.</p><p><b>RESULTS</b>A clonal population of B lymphocytes with typical characteristics of immunophenotype was identified in the patient. After treated with intrathecal chemotherapy, the patient returned to normal cells count of cerebrospinal fluid and normal neurologic status. Previous studies also have demonstrated the efficacy of intrathecal chemotherapy.</p><p><b>CONCLUSION</b>CNS invasion is a rare complication of CLL. Early detection and treatment may result in better outcomes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Leucemia Linfocítica Crônica de Células B
/
Sistema Nervoso Central
/
Infiltração Leucêmica
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2014
Tipo de documento:
Artigo
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