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Clinical investigation of reduced-dose voriconazole on primary prevention in invasive fungal disease after allogeneic hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology ; (12): 577-580, 2014.
Artigo em Chinês | WPRIM | ID: wpr-242112
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and tolerability of intravenous voriconazole on primary prevention in invasive fungal disease (IFD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>At the time of conditioning regimen, patients without IFD was intravenously administered with voriconazole at a dose of 100 mg two times per day until neutrophils greater than 0.5×10⁹/L. Patients treated with oral fluconazole, 200 mg per day, were control group. The incidence and risk factors of IFD and side effects of medicines were evaluated.</p><p><b>RESULTS</b>Of the total 227 patients, 33 (14.54%) had IFD within 3 months after allo-HSCT. There was significant difference on overall survival between patients with or without IFD by Kaplan-Meier survival curve (P=0.029). Of the 83 cases with intravenous voriconazole, 7 cases occurred IFD (8.43%). In contrast, the incidence of IFD in control group was 18.06% (26 out of 144). There was remarkable difference between the two groups (P=0.048). But there was no significant difference on risk factors of IFD between the two groups. In addition, the incidence of liver function abnormalities between the two groups was no difference. The ratio of auditory hallucination and visual impairment induced by voriconazole was not high.</p><p><b>CONCLUSION</b>Intravenous voriconazole on primary prevention for IFD after allo-HSCT is much better than oral fluconazole with well tolerability and satisfactory efficacy.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Complicações Pós-Operatórias / Fluconazol / Seguimentos / Resultado do Tratamento / Transplante de Células-Tronco Hematopoéticas / Usos Terapêuticos / Administração Intravenosa / Voriconazol / Micoses / Antifúngicos Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Criança / Criança, pré-escolar / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Complicações Pós-Operatórias / Fluconazol / Seguimentos / Resultado do Tratamento / Transplante de Células-Tronco Hematopoéticas / Usos Terapêuticos / Administração Intravenosa / Voriconazol / Micoses / Antifúngicos Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Criança / Criança, pré-escolar / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2014 Tipo de documento: Artigo