Protective effect and mechanism of β-CM7 on renin angiotensin system & diabetic cardiomyopathy / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 195-203, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-242301
ABSTRACT
This article aimed at exploring the effects and protective mechanism of β-CM7 on renin angiotensin system (RAS) in diabetic rats myocardial tissue. We divided 32 male SD rats into 4 groups control group, diabetic model control group, insulin (3.7x10(-8) mol/d) treatment group and β-CM7 (7.5x10(-8) mol/d) treatment group. After 30 days, all rats were decapitated and myocardical tissues were collected immediately. After injection, β-CM7 could decrease the content of Ang II, increase the content of Angl-7. And β-CM7 could improve the mRNA of AT1 receptor and Mas receptor. β-CM7 also could improve the mRNA of ACE and ACE2, enhance the activity of ACE and ACE2. These data confirmed tli β-CM7 could activate ACE2-Angl-7-Mas axis, negative passage in RAS, to inhibit the expression ACE mnRiJA and protein in rat myocardium, alleviate the myocardial tissue damage induced by Ang II. The effect of β-CM7 on inhibiting myocardium damage might be related to ACE/ACE2 passageway.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fragmentos de Peptídeos
/
Farmacologia
/
Sistema Renina-Angiotensina
/
RNA Mensageiro
/
Angiotensina II
/
Endorfinas
/
Ratos Sprague-Dawley
/
Peptidil Dipeptidase A
/
Receptores Acoplados a Proteínas G
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2016
Tipo de documento:
Artigo
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