Effect of beta3-adrenergic agonists on alveolar fluid clearance in hypoxic rat lungs / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1028-1033, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-242524
ABSTRACT
<p><b>BACKGROUND</b>Recent research suggests that beta(2)-adrenergic agonists increase alveolar fluid clearance (AFC) under physiologic and pathologic conditions. It is unknown whether beta(3)-adrenergic agonists also increase AFC under pathologic conditions. The aim of this study was to investigate the effect of beta(3)-adrenergic agonists on AFC following hypoxic lung injury and the mechanisms involved.</p><p><b>METHODS</b>Hypoxic rats were exposed to 10% oxygen. BRL-37344 (beta(3)-adrenergic agonist) or CGP-12177 (selective beta(3)-adrenergic agonist) alone or combined with beta receptor antagonists, sodium channel blockers, or Na(+)/K(+)-ATPase blockers were perfused into the alveolar space of rats exposed to 10% oxygen for 48 hours. Total lung water content (TLW) and AFC were measured.</p><p><b>RESULTS</b>AFC did not change for the first 24 hours but then decreased after 48-hour exposure to 10% oxygen. The perfusion of BRL-37344 or CGP-12177 significantly increased AFC in normal and hypoxic rats. The AFC-stimulating effect of CGP-12177 was lowered with amiloride (a Na(+) channel blocker) and ouabain (a Na(+)/K(+)-ATPase inhibitor) by 37% and 49%, respectively. Colchicine significantly inhibited the effect of CGP-12177.</p><p><b>CONCLUSIONS</b>These findings suggest that beta(3)-adrenergic agonists can increase AFC during hypoxic lung injury in rats and accelerate the amelioration of pulmonary edema.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Propanolaminas
/
Alvéolos Pulmonares
/
Edema Pulmonar
/
Líquidos Corporais
/
Ratos Wistar
/
Agonistas Adrenérgicos beta
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Etanolaminas
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2010
Tipo de documento:
Artigo
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