Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 179-188, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-242825
ABSTRACT
In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL), i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations. For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field, which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Terapia Genética
/
Engenharia Genética
/
Transplante de Células-Tronco
/
Prática Clínica Baseada em Evidências
/
Genética
/
Perda Auditiva Neurossensorial
/
Camundongos Endogâmicos C57BL
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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