Effects of clotrimazole on the growth of oral squamous cell carcinoma / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 545-548, 2010.
Article
em Zh
| WPRIM
| ID: wpr-243147
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>to investigate the effects of clotrimazole on the growth of oral squamous cell carcinoma (OSCC).</p><p><b>METHODS</b>OSCC-25 cells growing in log phase were treated with various doses of clotrimazole. The concentration of IC(50), cell cycle and cell cycle related protein were examined.</p><p><b>RESULTS</b>the concentration of clotrimazole for inhibiting OSCC was IC(50) 8.51 µmol/L. Clotrimazole induced cell cycle arrest in the G(0)-G(1) cell cycle phase, with a concomitant decrease of cells in the G(2)-M and S-phase. Furthermore, clotrimazole significantly decreased the levels of cyclin D, cyclin E and CDK-4.</p><p><b>CONCLUSIONS</b>clotrimazole inhibits the growth of OSCC.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
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Neoplasias Bucais
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Carcinoma de Células Escamosas
/
Ciclo Celular
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Divisão Celular
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Clotrimazol
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Proteínas Oncogênicas
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Ciclina E
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Linhagem Celular Tumoral
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2010
Tipo de documento:
Article