Three times spontaneous remission of severe aplastic anemia following granulocyte transfusion from related donors: a case report and literature review / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 58-60, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-243217
ABSTRACT
Aplastic anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells and bone marrow failure. Currently, hematopoietic stem cell transplantation (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion adjuvant therapy, hematopoietic growth factors, and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST. This article reported a severe AA patient who failed to respond to IST, but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity, which might explain this patient's recovery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Remissão Espontânea
/
Terapêutica
/
Transplante
/
Transfusão de Leucócitos
/
Alergia e Imunologia
/
Granulócitos
/
Anemia Aplástica
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS