Epigenetic mechanism of RUNX1 in pathogenesis of leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 525-530, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-243320
ABSTRACT
RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may receive a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoietic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Leucemia
/
Processamento de Proteína Pós-Traducional
/
Epigênese Genética
/
Subunidade alfa 2 de Fator de Ligação ao Core
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2010
Tipo de documento:
Artigo
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