The expression and significance of CD151 in pituitary adenomas / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 182-185, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-243388
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression and significance of CD151 in pituitary adenomas.</p><p><b>METHODS</b>Thirty-six pituitary adenomas were collected immediately after surgery together with five normal pituitary tissue. Real time-PCR, Western blot and immunohistochemistry analysis were performed to detect the expression of CD151 mRNA and protein in thirty-six pituitary adenomases and five normal pituitary tissues.</p><p><b>RESULTS</b>The expression of CD151 in all pituitary adenomases was observed to be significantly higher than that in normal pituitary tissues by Western blot, real time PCR, and immunohistochemistry analysis (P < 0.01). The expression levels of protein and mRNA in invasive pituitary adenomas were much higher than those in non-invasive pituitary adenomas (P < 0.01).</p><p><b>CONCLUSION</b>The results suggested that the expression of CD151 was closely correlated with malignant degree of pituitary adenomas, which indicated the expression of CD151 was intimately correlated with occurrence and development of pituitary adenomas. Detecting CD151 might be a vital index to predict prognosis of pituitary adenomas.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Hipófise
/
Neoplasias Hipofisárias
/
Prognóstico
/
RNA Mensageiro
/
Imuno-Histoquímica
/
Adenoma
/
Western Blotting
/
Tetraspanina 24
/
Reação em Cadeia da Polimerase em Tempo Real
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2015
Tipo de documento:
Artigo
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